Diabetes Mellitus Affects Working Memory

Alzheimer’s disease (AD) degrades the brain’s ability to remember, think, and carry out tasks. The exact cause is not known, but several risk factors have been identified, including diabetes mellitus (DM). DM causes elevated blood sugar levels due reduced insulin production in pancreas. linkage between glucose behavioral impairments are fully understood, which was focus of this study. Rats were trained alternate directions a maze receive reward on consecutive trials. After training, five rats injected with streptozotocin (STZ), induces hyperglycemia by injuring pancreatic beta cells. Three control animals received benign vehicle injections. All eight then underwent implant surgery an 128 recording probes attached electronic interface board. electrodes targeted hippocampus anterior cingulate cortex (ACC), both associated learning memory processes. We found that STZ had accuracy after long delay periods compared rats. During task performance, there decrease power theta activity increase delta moments before starting new trial. This opposite animals, who trials higher less as they focused. These findings imply impaired longer periods. like reports from animal models AD may help explain why factor for AD.